by Stephen T. Abedon Ph.D. Steve Abedon, Ph.D., has taught well over 100 individual classes and ~10 individual courses (including introductory biology, microbiology, physiology, biochemistry, etc.) over his 30+ years as a college professor. He has over 150 publications, including multiple monographs, and is ranked in the top 1 or 2 percent among researchers of all disciplines worldwide. His research focuses on bacteriophage biology and phage therapy. (abedon.1@osu.edu)
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phage.org/terms/holin.html · Abedon’s Books · DOI: 10.5281/zenodo.20173633
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Holins are intimately involved in determining infection latent period length and mechanistically are responsible for allowing phage-produced endolysin to degrade the bacterial cell wall.
Holins are named after an ability to form "holes" in bacterial plasma membranes, thereby allowing endolysin to translocate from within the bacterial cytoplasm, where endolysin is produced, to the bacterial cell wall. Not all holins, however, function in precisely this manner.
Numerous reviews of holin function have been authored by Ry Young including Young (1992), Young and Bläsi (1995), Young (2005), and Young and Wang (2006).
Abedon, S.T. (2026). Phage Terms. https://terms.phage.org · 10.5281/zenodo.20173633
Every term in the Glossary of Bacteriophage Terms. The current page is highlighted purple.