🔬 Lysin

Enzyme employed by phages to break down the cell wall of infected bacteria towards release of intracellular phage particles to the extracellular milieu.

by Stephen T. Abedon Ph.D. Steve Abedon, Ph.D., has taught well over 100 individual classes and ~10 individual courses (including introductory biology, microbiology, physiology, biochemistry, etc.) over his 30+ years as a college professor. He has over 150 publications, including multiple monographs, and is ranked in the top 1 or 2 percent among researchers of all disciplines worldwide. His research focuses on bacteriophage biology and phage therapy. (abedon.1@osu.edu)

phage.org | phage-therapy.org | biologyaspoetry.org | abedon.phage.org | google scholar | publications

Jump to:   📖 Discussion  |  🔬 Phage Terms  |  🔤 Index  |  🧮 Calculators

About this entry: Lysin is one of a growing set of phage biology and phage therapy terms defined here. For more phage terms, see Abedon, S.T. (2025). Phage Therapy Annotated Glossary. Preprints.org. 10.20944/preprints202508.0347.v1
To share a particular section, use the 🔗 link beside its heading, which copies a web address that opens the page right there. To cite this page: Abedon, S.T. (2026). Phage Terms. terms.phage.org.  ·  DOI: 10.5281/zenodo.20173633

phage.org/terms/lysin.html  ·  Abedon’s Books  ·  DOI: 10.5281/zenodo.20173633

How can I improve this page?  contact: terms@phage.org

Lysin: Enzyme employed by phages to break down the cell wall of infected bacteria towards release of intracellular phage particles to the extracellular milieu.
Also in the Phage Therapy Annotated Glossary: see the entries “Endolysin” (p. 24) and “Lysin” (p. 33). Read the Glossary · Abedon, S.T. (2025). Preprints.org. doi:10.20944/preprints202508.0347.v1

Discussion

Lysins are more formally known as endolysins and the timing of their function is controlled by the action of holin proteins.

Endolysins can be differentiated into a number of different types depending on what chemical bonds on the bacterial cell wall they cleave, one variant of which can be described as a lysozyme.

Lysins can be employed as stand-alone antibacterial agents, so-called enzybiotics. Note further that a substantial number of lysin/endolysin/lysozyme reviews exist.

References

How to cite this page

Abedon, S.T. (2026). Phage Terms. https://terms.phage.org  ·  10.5281/zenodo.20173633

🔬 Phage Terms — Alphabetical Index

Every term in the Glossary of Bacteriophage Terms. The current page is highlighted purple.

Loading terms…

🔤 Index

🧮 Phage Biology and Phage Therapy Calculators

Loading calculators…