๐Ÿ”ฌ Destructive Infection

Phage-bacterial interaction in which the phage is inactivated.

by Stephen T. Abedon Ph.D. (abedon.1@osu.edu)

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About this entry: Destructive Infection is one of a growing set of phage biology and phage therapy terms defined here. For more phage terms, see Abedon, S.T. (2025). Phage Therapy Annotated Glossary. Preprints.org. 10.20944/preprints202508.0347.v1

phage.org/terms/destructive_infection.html  ·  Abedon’s Books  ·  DOI: 10.5281/zenodo.20173633

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Destructive Infection: Phage-bacterial interaction in which the phage is inactivated.

Discussion

<p>Phage-destructive infections include those mediated by restriction endonucleases, resulting in a "restricted" infection this is phage but not bacterial destructive. Abortive infections tend to be phage as well as bacterial destructive, though only so long as the mechanism gives rise to substantial reductions in efficiency of center of infection (Efficiency of center of infection">ECOI). CRISPR-associated mechanisms can give rise to either result, that is, bacterial survival or, instead, bacterial loss.

Strictly phage-mediated mechanisms that give rise to destructive infections include those that result in superinfection exclusion or, instead, superinfection immunity. See also the concept simply of superinfection.

External links

How to cite this page

Abedon, S.T. (2026). Phage Terms. https://terms.phage.org  ·  10.5281/zenodo.20173633

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Destructive Infection — terms.phage.orgphage.org — Stephen T. Abedon — Version 2026.05.14