๐Ÿ”ฌ Tailocin

An apparently defective prophage that can serve as an class="bap-term">antibacterial agent, where head and DNA is absent from an otherwise adsorption-competent Phage particle">phage particle.

by Stephen T. Abedon Ph.D. (abedon.1@osu.edu)

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About this entry: Tailocin is one of a growing set of phage biology and phage therapy terms defined here. For more phage terms, see Abedon, S.T. (2025). Phage Therapy Annotated Glossary. Preprints.org. 10.20944/preprints202508.0347.v1

phage.org/terms/tailocin.html  ·  Abedon’s Books  ·  DOI: 10.5281/zenodo.20173633

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Tailocin: An apparently defective prophage that can serve as an class="bap-term">antibacterial agent, where head and DNA is absent from an otherwise adsorption-competent Phage particle">phage particle.

Discussion

<p>From Gill and Young (2011), p. 377: "Many bacteria have taken advantage of the cellular leakage associated with the phage DNA ejection process by evolving 'tailocins', a term we propose here for what were originally called 'high-molecular weight pyocins' when they were first identified in Pseudomonas strains... Basically, these are the apparent products of degenerate prophage elements which lack head genes; when the tailocin determinants are expressed, headless phage particles are produced that appear to kill the target cells by the same hole-forming process used for phage DNA ejection, except that no DNA ever goes through to cause re-sealing of the hole. The new term tailocin is justified because the same entities have now been found in many other Prokaryotic species">bacterial species, and the continued use of the pyocin term would be misleading."

External links

References

  • Gill and Young (2011).

How to cite this page

Abedon, S.T. (2026). Phage Terms. https://terms.phage.org  ·  10.5281/zenodo.20173633

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Tailocin — terms.phage.orgphage.org — Stephen T. Abedon — Version 2026.05.14