🔬 Plaque-Forming Unit (PFU)

Discussion

<p>Plaque-forming units (PFUs) are equivalent in concept to colony-forming units (CFUs) when plating class="bap-term">bacteria, that is, where a single bacterium, bacterial arrangement, or clump of bacteria all can give rise to only a single colony upon plating.

From Gill and Young (2011), p. 403, "Analogous to the concept of a colony forming unit (CFU) in bacteriology. As a single virion initiates the formation of a single plaque, biology" class="bap-term">enumeration of PFU allows quantification of the number of phages in a given sample. Note that, as is the case with CFU, the number of PFU reflects the number of phages able to form plaques in a sample, not the total number of virions." E., Lingohr, E., and Johnson, R. P. Enumeration of bacteriophages by double agar overlay plaque assay. Methods in Molecular Biology 501, 69-76. 2009.>

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